Gel-Based Treatment Successfully Prevents Glioblastoma Recurrence in Mice

A new therapy has been found to prevent aggressive brain cancer recurrences in mice
The new gel-based therapy for glioblastoma, a highly aggressive brain cancer, has shown 100% effectiveness in preventing recurrences in mice. Researchers hope that the therapy can be translated into human physiology where it may help to resolve tens thousands of cancer diagnosis each year.

Glioblastoma is a brain or spinal-cord tumor. Even after a glioblastoma patient has had the tumor surgically removed the mass will often return, even if they have received post-surgical chemotherapy or radiation. The disease is so persistent, that the average patient only lives 12 to 16 month after diagnosis. This makes glioblastoma the deadliest form of cancer known today.

Researchers at Johns Hopkins University have developed an injectable gel to block cancer’s progress. A paper published in Proceedings of National Academy of Sciences on Tuesday describes the gel as being made of nano-sized fibers that are derived from paclitaxel. This drug is also used to treat cancers other than breast. The gel is used to transport aCD47, a monoclonal antibody that triggers macrophages into ingesting tumor cells.


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