Exploring the Neurodevelopmental Enhancer Potential of Human Accelerated Regions with Machine Learning
Machine learning dissections of human accelerated areas in primate neurodevelopment
Whalen et al. Deep learning and functional assays on chimpanzees and human cells are combined to examine the neurodevelopmental enhancement potential of 2,645 accelerated human regions (HARs). The activity is dominated more by cis than trans effects. Compensatory changes have been identified as a key driver for rapid HAR evolution.